Ok, I haven't tested with the win32com module yet, but simply getting mod_python running was easy: 1. Download the win32 build of mod_python from here: http://httpd.apache.org/modules/python-download.cgi 2. When the installer asks you where your apache installation is, point it to UNISERVER_FOLDER/udrive/usr/local/apache2 (Where UNISERVER_FOLDER is the folder on disk where you've put your Uniform Server). This simply tells the installer where to find the /modules directory off of your apache2 directory, which is where mod_python.so belongs 3. Add the following line to apache.conf: LoadModule python_module modules/mod_python.so 4. Set the handling method of your choice as described here: http://webpython.codepoint.net/mod_python_...e_configuration